Elastin overexpression by cell-based gene therapy preserves matrix and prevents cardiac dilation
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چکیده
منابع مشابه
Elastin overexpression by cell-based gene therapy preserves matrix and prevents cardiac dilation
After a myocardial infarction, thinning and expansion of the fibrotic scar contribute to progressive heart failure. The loss of elastin is a major contributor to adverse extracellular matrix remodelling of the infarcted heart, and restoration of the elastic properties of the infarct region can prevent ventricular dysfunction. We implanted cells genetically modified to overexpress elastin to re-...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2012
ISSN: 1582-1838
DOI: 10.1111/j.1582-4934.2012.01560.x